FAQ Tag: prostrate cancer
What is PARP?
Poly-ADP-ribose polymerase (PARP) plays an important role in DNA damage detection and repair. It is typically implicated in ovarian, breast, and pancreatic tumors harboring BRCA1/2 mutations, as well as castration-resistant prostate cancers with homologous recombination repair (HRR) mutations (Pham et al., 2021, Trends Cancer).
What is BRCA1/2
BRCA1/2 are tumor suppressors. They protect cells from transformation; when mutated cells can progress to cancer, usually in combination with other genetic changes. BRCA1 is involved in the DNA repair process, where it recruits other factors to carry out DNA repair through the process of homologous recombination. It mediates the sensors and effectors in DNA…
What is hormonal therapy?
Hormonal therapy is a type of cancer treatment that is used to slow down or stop the growth of certain types of cancer that are hormone-sensitive. Hormonal therapy is also known as hormone therapy, endocrine therapy or anti-hormone therapy.
