FAQ Tag: breast cancer
What are CDK4/6 inhibitors?
CDK4/6 inhibitors are a class of medicines used to treat certain types of hormone receptor-positive, HER2-negative breast cancer. These medicines interrupt the process through which breast cancer cells divide and multiply. Some examples include palbociclib, abemaciclib and ribociclib. (Sobhani et al., 2019, Cells)
What is PARP?
Poly-ADP-ribose polymerase (PARP) plays an important role in DNA damage detection and repair. It is typically implicated in ovarian, breast, and pancreatic tumors harboring BRCA1/2 mutations, as well as castration-resistant prostate cancers with homologous recombination repair (HRR) mutations (Pham et al., 2021, Trends Cancer).
What is BRCA1/2
BRCA1/2 are tumor suppressors. They protect cells from transformation; when mutated cells can progress to cancer, usually in combination with other genetic changes. BRCA1 is involved in the DNA repair process, where it recruits other factors to carry out DNA repair through the process of homologous recombination. It mediates the sensors and effectors in DNA…
What is HER2 receptor?
HER2 (human epidermal growth factor receptor 2) is a type of protein that is found on the surface of some cells, including breast cells. HER2 receptors play a critical role in cell growth and division, and they are involved in the development and progression of some types of cancer. HER2-positive breast cancer is a type…
Should I reconstruct?
[Answer from panel of doctors] Here’s a poll of other survivors on this topic:
What is hormonal therapy?
Hormonal therapy is a type of cancer treatment that is used to slow down or stop the growth of certain types of cancer that are hormone-sensitive. Hormonal therapy is also known as hormone therapy, endocrine therapy or anti-hormone therapy.
