FAQ Category: Technical
What is Crizotinib?
Crizotinib, sold under the brand name Xalkori among others, is an anti-cancer medication used for the treatment of non-small cell lung carcinoma (NSCLC) and relapsed anaplastic large cell lymphoma (Passerini et al., 2014, JNCI). It inhibits the action of the EML4-ALK fusion protein as an inhibitor (Lei et al., 2022, Oncol Lett).
What are CDK4/6 inhibitors?
CDK4/6 inhibitors are a class of medicines used to treat certain types of hormone receptor-positive, HER2-negative breast cancer. These medicines interrupt the process through which breast cancer cells divide and multiply. Some examples include palbociclib, abemaciclib and ribociclib. (Sobhani et al., 2019, Cells)
What is PARP?
Poly-ADP-ribose polymerase (PARP) plays an important role in DNA damage detection and repair. It is typically implicated in ovarian, breast, and pancreatic tumors harboring BRCA1/2 mutations, as well as castration-resistant prostate cancers with homologous recombination repair (HRR) mutations (Pham et al., 2021, Trends Cancer).
What is BRCA1/2
BRCA1/2 are tumor suppressors. They protect cells from transformation; when mutated cells can progress to cancer, usually in combination with other genetic changes. BRCA1 is involved in the DNA repair process, where it recruits other factors to carry out DNA repair through the process of homologous recombination. It mediates the sensors and effectors in DNA…
What is HER2 receptor?
HER2 (human epidermal growth factor receptor 2) is a type of protein that is found on the surface of some cells, including breast cells. HER2 receptors play a critical role in cell growth and division, and they are involved in the development and progression of some types of cancer. HER2-positive breast cancer is a type…
What are the side effects of chemotherapy?
Side effects of chemotherapy differ from person to person as well as the type of drug combination that was used. Some common side effects include:
How should I manage the changes to my nails?
Some steps you could take to manage the changes in your nails include: (Source: Breastcancer.org)
Why do my toenails look bruised after chemotherapy?
Some drugs… Examples include tamoxifen, doxorubicin, daunorubicin, ixabepilone, mitoxantrone and docetaxel.
What is denosumab?
Denosumab (also known as Prolia and Xgeva) is a human monoclonal antibody (hence the mab at the back of its name) used to treat bone destruction due to metastatic cancer, osteoporosis and rheumatoid arthritis (RA).
What is monoclonal antibody?
Monoclonal antibodies (mAbs) are a type of medicine that are specifically created in the lab to invoke your immune system to start targeting cancer cells and/or infections in general. This is typically known as immunotherapy. Most of the time, the names of monoclonal antibody drugs end with the suffix -mab (e.g., denosumab).
